Serologic Results to Diagnostic Interpretation

Interpretation of HIV serologic testing results.

A 33-year-old male patient visited the outpatient clinic at Brigham and Women’s Hospital for a routine follow-up for obesity, obstructive sleep apnea, allergic rhinitis, and depression. He was maintained on a nocturnal continuous positive airway pressure device, loratadine, duloxetine, and fluticasone nasal spray. He was a resident of Boston and had not traveled outside the country. He denied i...

Ensuring correct interpretation of diagnostic test results.

Editor's Note Ensuring Correct Interpretation of Diagnostic Test Results Today, physicians order a wide array of diagnostic laboratory and imaging tests for their patients, including genetic evaluations.Tomakesenseof thegrowingnumberofdiagnostic testing opportunities, one might expect that physicians, in turn, have grown in their ability to accurately interpret test results. The Research Letter...

Interpretation of Serologic Test Results and Evaluation of Humoral Immune Response After Vaccination Following Infection with COVID-19 Disease

SARS-CoV-2 virus infection induces a cellular and humoral mediated immune response and produces antibodies against viral antigens such as nucleocapsid (N) protein and spike (S) protein. Anti-protein S antibodies also target the spike protein subunit S1 and the receptor binding domain (RBD). Serologic tests can detect the presence of these antibodies in blood serum within a few days to a few wee...

Lyme disease: How reliable are serologic results?

Visualization of microarray results to assist interpretation.

Whole genome microarrays allow assessment of the profile of genes expressed under particular experimental conditions, including external stimuli such as pH or temperature, and internal changes brought about by deleting or over-expressing a gene. Such experiments produce large data sets, for which sophisticated analysis software is available. What is lacking are tools for analysing data sets fro...